BSG and breast cancer: In addition to MMP induction, CD147 also participates in the activation of the urokinase-type plasminogen activator system in breast cancer, oral squamous cancer, trophoblasts and endothelial cells [136–138], as well as a disintegrin and metalloproteinase with thrombospondin motifs (ADAMTS)-1 and ADAMTS-9 production in cells infected with Kaposi's Sarcoma-associated herpes virus [139].