During the 53 weeks of the prospective study, the serum albumin level (41.5 ± 3.5 vs. 34.3 ± 3.9 g/dl, P < 0.0001) and HDL-cholesterol (40, 23–73 vs. 37, 21–71 g/dl, P < 0.05) were decreased, whereas the β2-microglobulin (2.35, 0.09–6.28 vs. 3.51, 0.50–9.97 mg/dl, P < 0.05), parathyroid hormone (PTH, 481, 4–1900 vs. 600, 5–1900 pg/ml, P < 0.05), and total alkaline phosphatase (ALP, 95, 47–354 vs. 123, 78–687 U/l, P < 0.05) were increased in LF-HD patients. The gene discussed is HLA-G; the disease is Huntington disease.