At 21 months after the study was completed, LF-HD and HF-HD patients did not differ in all-cause and cardiac mortality rates (Supplementary Figures 10 and 11), although these patients significantly differed in eQB (293 ± 43 vs. 355 ± 45 ml/min, respectively, P < 0.000001) and cTnT (0.046 ± 0.031 vs. 0.074 ± 0.061 ng/ml, respectively, P = 0.01) at the beginning of the 21-month observation period. Here, TNNT2 is linked to hydrops fetalis.