TP53 and cancer: All the seven sets share 9 genesincluding ATM, CDKN2A, EGFR, NF1, PTEN,RUNX1, SMARCA4, STK11 and TP53, and this highestorder intersection is highly significant, withFE = 5.7 × 1010and adjusted Pvalue = 4.3 × 10−93.This result is consistent with the well-recognized observations in large scalecancer genome discoveries that a few cancer genes are mutated in a highproportion of tumors of a given type (>20%) while most cancer genemutations are less common (2–20%)17.