HSPG2 and tuberculosis: Moreover, in a study on geneticpolymorphisms affecting the four PLC encoding genes in M. tuberculosisisolates, Viana-Niero and coworkers found that 19 of 25 clinical isolates showedloss of parts of genes or complete genes from the plcABC and/or plcDloci, whereby five isolates retrieved from patients with active tuberculosis had all4 plc genes interrupted48.