Considering that it is difficult to assess whether the endothelium produces fractalkine during human sepsis in vivo, we compared the kinetics of fractalkine release into the circulation relative to that of the established specific endothelial cell activation marker E-selectin [32, 33] in a controlled human setting of systemic inflammation induced by bolus intravenous injection of LPS. The gene discussed is SELE; the disease is Sepsis.