HDAC5 expression was altered in three phases: During ongoing EEG status epilepticus (2–12 h after KA injection), HDAC5 was rapidly increased by about 30–80% both in the granule cell layer of the injected and of the contralateral hippocampus at the 2 h interval and reached 205 ± 14.56% of controls (p < 0.001) at the injection site and 261 ± 31.36% of controls (p < 0.001) on the contralateral side 12 h after KA injection (Figs 3f and 4d). Here, HDAC5 is linked to status epilepticus.