By univariate analysis, overall survival in this study was found to be influenced significantly by advanced T stage (T3 or T4) (p = 0.015), lymph node metastases (p = 0.021), positive lymphvascular invasion (p = 0.024), positive perineural invasion (p = 0.041), poor differentiation (p = 0.013), AJCC stage (p = 0.021) and CK7+/CK20- (p = 0.036) (Table 2). This evidence concerns the gene KRT7 and metastatic malignant neoplasm in the lymph nodes.