VEGFA and cancer: Next, we examined Lysm+/Cre;Vegfafl/fl mice, which are deficient in myeloid cell–derived Vegfa and were previously shown to have reduced pathological angiogenesis in wound healing and cancer models.22,24Lysm+/Cre;Vegfafl/fl mice appeared healthy as previously reported and had normal retinal angiogenesis (Figure IA in the online-only Data Supplement).