Similarly, overexpression (Fig. 2f) or targeted knockdown (Fig. 2f) of β-catenin lead to an increase or decrease, respectively, of the MGMT promoter in SK-N-AS neuroblastoma, DAOY medulloblastoma, SW480 and LS174T colon carcinoma cells (Fig. 2f). The gene discussed is MGMT; the disease is medulloblastoma.