We also detected a correlation between β-catenin as shown by western blots against the active form of β-catenin dephosphorylated on Ser37 or Thr41 and the downstream effector Axin 2 and MGMT expression in the majority of cancer cell lines derived from these cancers (Fig. 1d,e, Supplementary Fig. 7a). The gene discussed is AXIN2; the disease is cancer.