We further attempted to clarify the mechanisms underlying the osteogenic capability of OM or OM(Dex) with EGCG by using alizarin red staining and inhibitors of four signal transduction pathways: PD98059 for ERK1/2, API-2 for Akt, SB203580 for p38-MAPK, and SP600125 for JNK (Figure 4). This evidence concerns the gene AKT1 and ocular melanoma.