Infection with wt Mtb, MtbΔRD1::RD1 and, slightly, MtbΔRD1::B412, stimulated IRF3 phosphorylation, while minor modifications were detected in DC infected with BCG recombinants providing evidences for the IRF3-dependent transcriptional induction of IFNB1 and IL29 genes shown in Fig. 3. The gene discussed is IRF3; the disease is infection.