To identify BER factors essential for repair of ß-lap-induced DNA base and SSB lesions, a pooled RNAi screen against a limited and focused number of BER proteins was performed in NQO1+ MiaPaca2 PDA cells, including: FLAP endonuclease 1 (FEN1), XRCC1, AP endonuclease 1 (APE1), OGG1 and methyl-purine-DNA glycosylase (MPG) genes/proteins. The gene discussed is XRCC1; the disease is Patent ductus arteriosus.