EGFR and breast carcinoma: In addition to CD24, FAK, EGFR, and Survivin, BrCa serum EVs have been found to contain the disintegrin and metalloprotease ADAM10, as well as the tetraspanin CD9 [41, 65, 70], with the latter being a known functional integrin binding partner in breast cancer cells [71, 72] and a molecular marker of EVs.