More recently, we applied the conditional Cre-Flex LV technology to specifically label the NSCs of the SVZ in Nestin-Cre mice, that enabled us to monitor the neurogenic response in a stroke model, demonstrating that nestin+ NSCs originating from the SVZ respond to stroke injury by increased proliferation and migration of their progeny towards the infarct region [23]. The gene discussed is NES; the disease is stroke disorder.