Previous reports have demonstrated a role for SHARPIN in Tumor Necrosis Factor (TNF, also known as TNFα) induced NF-κB activity in MEFs, keratinocytes, B-cells and hepatocytes [6–8,16], as well as in activated B-cell like diffuse large B-cell lymphoma [17], PC3 and DU145 prostate cancer cells [18]. This evidence concerns the gene TNF and Familial prostate cancer.