These include in particular Th1-cell lineage which are pro-atherogenic via the secretion typically of IFN-γ and TNF-α, and Th2-cell lineage secreting IL-4, IL-10 and IL-13 whom their role in atherosclerosis remains controversial, including Th1 and Th2 cells [35,36]. The gene discussed is TNF; the disease is atherosclerosis.