Indeed, the patients presenting with neonatal diabetes mellitus (NDM), maturity-onset diabetes of the young (MODY), or adult onset atypical type 2 diabetes, who carry a heterozygous mutation in ABCC8 or KNCJ11 (encoding subunits of the ATP-dependent potassium channel at the membrane of pancreatic beta cells), can be successfully switched from an expansive and demanding insulin therapy to easy and cheap oral sulfonylureas, with much better result on glucose control [1]. This evidence concerns the gene INS and neonatal diabetes mellitus.