To elucidate and distinguish the effects of GHRL rs26311 polymorphism on HBV-related LC through direct influence on LC progression or indirect influence as induced by HBV, CHB patients were also selected as a control group, and binary logistic regression was used to estimate ORs and 95% CIs after adjusting for gender and age to test the relationship between the rs26311 polymorphism and the risk of LC compared with CHB patients. The gene discussed is GHRL; the disease is laryngotracheoesophageal cleft.