They contained 284 chronic hepatitis C Spanish patients, and found that GHRL SNPs rs26312 and rs27647 influenced the progression of liver fibrosis in patients with chronic hepatitis C. Another study assessed the relationship of progression of HCC with the GHRL rs27647, rs34911341, and rs696217 polymorphisms in 40 Egyptian patients with chronic hepatitis C, 39 patients with HCV-related HCC, and 40 healthy subjects [26]. This evidence concerns the gene GHRL and chronic hepatitis C virus infection.