These and other questions should be possible to address using inducible Pdgfb and Pdgfrb ablation as well as by crossing current models of PFBC, such as Pdgfbret/ret, into different sensitized or protective genetic backgrounds, and by exposing them to different systemic challenges, such as the induction of mineral imbalances. The gene discussed is PDGFRB; the disease is bilateral striopallidodentate calcinosis.