In SC adipose tissue, the mRNA levels of VEGF-A and FGF-2 were significantly reduced by 83% (p<0.05) and 29% (p<0.05), respectively, whereas TSP-1 mRNA level was increased by 11% in ALS-treated mice compared to control mice (Fig 6B). The gene discussed is VEGFA; the disease is amyotrophic lateral sclerosis.