In contrast to the data of Maquoi et al, Chavey et al found that mRNA levels for MMP-2, -3, -12, -14, -19 and TIMP-1 were strongly induced in obese adipose tissue, but MMP-7 and TIMP-3 mRNAs are markedly decreased in obesity. The gene discussed is TIMP1; the disease is obesity due to melanocortin 4 receptor deficiency.