In contrast, TIMP-1 and TIMP-2 mRNA levels were significantly increased by 69% (p<0.05) and 31% (p<0.05), respectively, in VSC adipose tissue (Fig 6A) and significantly increased by 122% (p<0.05) and 43% (p<0.05), respectively, in SC adipose tissue (Fig 6B) from ALS-treated mice compared to control mice. Here, TIMP2 is linked to amyotrophic lateral sclerosis.