Moderate-to-significant associations were observed between the reported risk alleles for T2D of rs10010131 in WFS1, rs7756992 in CDKAL1, rs10811661 near CDKN2BAS, rs2237895 in KCNQ1, rs8050136 and rs9939609 in FTO, rs7501939 in TCF2 and the increased risk for the concurrence of T2D and each MetS component (P values ranged from 3.42 × 10−6 to 5.61 × 10−2). This evidence concerns the gene WFS1 and metabolic syndrome.