MTNR1B and metabolic syndrome: However, the association could be driven by the genetic loci of which the T2D risk allele was related to a decreased risk for abdominal obesity, including BCL11A, MTNR1B, and KCNQ1. In addition, GRS was not associated with the other MetS components in T2D, which might be partly due to the antagonistic role of the T2D risk alleles.