The T2D risk allele of rs7903146 in TCF7L2 specifically contributed to an increased risk for T2D combined with abdominal obesity (P = 3.77 × 10−2) and the T2D risk allele of rs7961581 in TSPAN8/LGR5 was related to an increased risk for T2D with elevated TG level (P = 4.61 × 10−2). Here, TSPAN8 is linked to type 2 diabetes mellitus.