KLK3 and Familial prostate cancer: Other potential blood and urine based biomarkers for prostate cancer include: prostate cancer antigen 3 [PCA3] [11], intracellular PSA [12], PSA derivatives [13], early prostate cancer antigen 2 [14], annexin A3 [15], the fusion gene TMPRSS2:ERG [16, 17], human kallikrein 2 [18] and the Engrailed-2 protein (EN2) [19, 20].