By contrast, alternatively-activated macrophages induced by Th2 cytokines, such as IL-4 or IL-13 (to yield M2a macrophages), immune complexes in combination with IL-1β or LPS (to yield M2b macrophages), or IL-10, TGFβ or glucocorticoids (to yield M2c macrophages), can contribute to wound-healing and immune regulation, as well as tumor progression[2,6–10]. The gene discussed is TGFB1; the disease is neoplasm.