Further evaluation of the obesity-related loci from VIVA LA FAMILIA in IRASFS revealed nominal association for rs2823615 (PDOM = 7.86x10-3 with SAT), an intronic SNP in the Family with Sequence Similarity 222 Member A gene (FAM222A). The gene discussed is FAM222A; the disease is obesity due to melanocortin 4 receptor deficiency.