Specifically, IL-8 mRNA was mildly up-regulated by HRV16 in both healthy and CF HBE cells (<15-fold increase; Fig 3D), and the magnitude of this up-regulation was within the same order of magnitude as that of the secreted protein (respectively, Fig 3D vs. Fig 3B). The gene discussed is CXCL8; the disease is cystic fibrosis.