The expression of several TRIM genes including TRIM3, TRIM7, TRIM14, TRIM16, TRIM21, TRIM22, TRIM29, TRIM59, TRIM66 and TRIM70 was significantly upregulated in NSCLC cell lines compared with HBE cells(Fig 1A and 1B), whereas the expression of other TRIM genes including TRIM4, TRIM9, TRIM36, TRIM46, TRIM54, TRIM67 and TRIM76 was significantly down-regulated in NSCLC cell lines compared with that in HBE cells (Fig 1A and S1 Fig). The gene discussed is TRIM4; the disease is non-small cell lung carcinoma.