As the prevalence of the PNPLA3-high risk genotype (G/G) is reported to be very low in European CHC collectives (3–12% [23,39,53], being 5.1% in our cohort and 5.4% in another Austrian collective[40]) and the presence of a high-risk PNPLA3 allele did not show any impact on liver disease progression in HIV/HCV coinfection, we would not recommend to use PNPLA3 genotyping in daily clinical routine. This evidence concerns the gene PNPLA3 and cryohydrocytosis.