PNPLA3 and fatty liver disease: We aimed to assess the impact of PNPLA3 SNP (rs738409) on (i) fibrosis progression rate and development of advanced fibrosis, (ii) liver steatosis, (iii) portal hypertension, and (iv) virological response to PEGIFN/RBV therapy in a large cohort of HIV/HCV coinfected patients.