Not surprisingly, patients with advanced fibrosis showed a significantly longer duration of infection (16.2±9.6 vs. 10.0±9.7 years; p<0.01), a significantly lower CD4+ cell count (465±271 vs. 549±258cells/μL; p = 0.02), a significantly lower CD4-nadir (207±166 vs. 296±206 cells/μL; p = 0.01), and lower HDL-Cholesterol (40±17 vs. 49±18mg/dL; p<0.01). Here, CD4 is linked to infection.