MMP2 and metastatic malignant neoplasm in the lymph nodes: Table 1 shows that the CHD1L expression in breast cancer was significantly associated with lymph node metastasis (P = 0.008), tumor grade (P = 0.020), distant metastasis (P = 0.026), MMP-2 (P = 0.035), and MMP-9 expression (P = 0.022) (Fig 1B). Significant association was not found between CHD1L expression and tumor size, age, and hormonal status (Table 1).