LRP1 and Tremor: In knockout mouse models, LRP1 deficiency is lethal early in development (12), whereas neuron-specific LRP1 cre-lox mice exhibit severe tremor and dystonia, behavioral abnormalities, hyperactivity, age-dependent dendritic spine degeneration, synapse loss, neuroinflammation, memory loss, eventual neurodegeneration, and premature death (13, 14).