The patients with bladder cancer had a significantly higher frequency of the IL-22 -429 TT genotype (OR=2.04, 95% CI=1.19, 3.49; p=0.009) and -429 T allele (OR=1.42, 95% CI=1.08, 1.87; p=0.01) than the healthy control subjects (Table 3). The gene discussed is IL22; the disease is urinary bladder cancer.