HTRA1 and age-related macular degeneration: Among the AMD susceptibility loci [6–11], we identified two SNP variants that mutated A69 of the ARMS2 protein into alanine (A69S) (T/T for rs10490924) and a variation with high risk (A/A) in the promoter of the HTRA1 gene at rs11200638, since these SNP variants are predictive of AMD incidence with high odds ratios (2.86) by GWAS analyses of large numbers of patients with AMD [10].