Through genome-wide association studies (GWASs) on large populations of patients with AMD that included independent groups, several SNP susceptibility variants were identified in genes encoding complement factor H (CFH), high-temperature requirement factor A1 (HTRA1) and age-related maculopathy susceptibility 2 (ARMS2), as well as in the regions for TNFSF10A-LOC389641 and REST-C4orf14-POLR2B-IGFBP7 for dry-type [9] and for wet-type AMD [10, 11]. This evidence concerns the gene HTRA1 and age-related macular degeneration.