Additionally, we found cortisol-cortisone converting enzyme Hsd11b1 is correlated to Hh-signaling activation from several reports in several model systems including fetal prostate, prostate cancer and embryonic fibroblast cell lines [56, 64], indicating cortisone converted from cortisol by Hsd11b1 may account for part of the Hh response gene profile. This evidence concerns the gene HSD11B1 and prostate cancer.