Indeed, GLP-1 receptor (GLP-1R) agonists and dipeptidyl peptidase-4 (DPP-4) inhibitors, which increase endogenous GLP-1, are widely reported to protect cardiomyocytes from acute ischemia and improve functional recovery after myocardial infarction (MI) [6, 42]. This evidence concerns the gene GCG and myocardial infarction.