CXCR4 and neuropathy: In antiretroviral toxic neuropathy model, Bhangoo and colleagues have observed up-regulation of SDF1 and CXCR4 mRNA at 7 and 14 days after administration of antiretroviral drug 2, 3-dideoxycytidine, and the enhanced expression of SDF1 was mostly observed in the DRG non-neuronal cells [49].