The patients with LN metastasis were found to be more likely to relapse, the hazard ratio of DFS is 2.054 (P < 0.01), indicating that such patients may have about 2 times more risk of breast cancer relapse; and the hazard ratio of DFS for TGF-β is 0.469 (P < 0.01), indicating that those with negative TGF-β might reduce the relapse risk by about 53.1 %. The gene discussed is TGFB1; the disease is breast carcinoma.