Analogously, the results showed that in the positive group, larger tumor size, higher proportion of axillary lymph node metastasis and later clinical stages were observed, and that the two groups displayed no significant distinction in patients’ age, skin involvement, degrees of pathological differentiation, pathologic type of cancer, level of estrogen receptor (ER) and HER-2 (Table 2). This evidence concerns the gene ESR1 and neoplasm.