Based on the results from the multivariate COX’s Proportional Hazard Model to evaluate the clinical values of TGF-β/PTHrP in prognosis, it was found that the abnormal expression of TGF-β was an independent prognostic factor for DFS in breast cancer patients (HR = 0.469, 95.0 % CI 0.301 to 0.729; P < 0.05). This evidence concerns the gene PTHLH and breast cancer.