The top KEGG pathways associated with the 240 overlapped genes includes “ECM-receptor interaction”, “Pathways in cancer”, “Complement and coagulation cascades”, “Jak-STAT signaling pathway”, “Focal adhesion”, “Small cell lung cancer”, and “TGF-beta signaling pathway” (Supplementary Fig. S2), which suggests the depth of involvement of NFE2L2-mediated genes in human cancer. This evidence concerns the gene SOAT1 and cancer.