An age-dependent increase in glucose levels was observed in SENP1-AdipoqKO, SENP1-PdgfRKO and SENP1-aP2KO mice compared with the control SENP1lox/lox mice with an early onset of diabetes in SENP1-PdgfRKO at the age of 6 weeks (blood glucose level >225 mg dl−1); this earlier onset of hyperglycaemia is consistent with the high efficiency of PdgfRα-Cre in adipocyte progenitors. The gene discussed is PDGFRA; the disease is diabetes mellitus.