To investigate possible function of SENP1 in inflammation and diabetes, we created genetically modified mice with an adipocyte-specific deletion of SENP1 with three different deleter lines carrying the Cre recombinase driven by the Adiponectin, PdgfRα or aP2/Fabp4 gene promoter (named as SENP1-AdipoqKO, SENP1-PdgfRKO and SENP1-aP2KO, respectively; Supplementary Fig. 1A). Here, ADIPOQ is linked to diabetes mellitus.