In the present study, we have employed three different adipocyte-specific Cre deleter lines (Adipoq-Cre, PdgfRα-Cre and aP2/FABP4-Cre) and demonstrated that adipocyte-specific SENP1-deficient mice gradually develop a T1DM phenotype, including hyperglycaemia, reduced insulin secretion, glucose intolerance and weight loss. This evidence concerns the gene SENP1 and type 1 diabetes mellitus.