The input in this case should be an intra-tumour map from aspecific functional imaging tool, and a model analogous to the present one forthe corresponding sub-volume radiosensitivity, including its LET dependence.Examples are stem cells niches14, which could be identified byimaging their related marker CD133 by 64Cu-ATSM tracer (copper-diacetyl-methylthiosemicarbazone)51, or even withnear-infrared fluorescence molecular tomography52, and regions ofincreased repair activity through γH2AX labeling53, 54. This evidence concerns the gene PROM1 and neoplasm.