A boy with autism and his father with severe language delay had a frameshift mutation within NRXN2 exon 12 (Gauthier et al., 2011), whereas a 21-year-old man with a clinical phenotype including autistic traits, such as speech and language deficits and insistence on routine, had a 570-kb de novo deletion of 24 genes at chromosome 11q13.1, including NRXN2 (Mohrmann, Gillessen-Kaesbach, Siebert, Caliebe, & Hellenbroich, 2011). This evidence concerns the gene NRXN2 and autism.