All patients were negative for anti-Ro/SSA and anti-La/SSB antibodies, and none of them had Keratoconjunctivitis sicca symptoms or positive responses to subjective symptoms related to Sjögren ́s syndrome (dryness feeling in eyes, lip and the nose - questions 9, 10 and 11 of xerostomia Inventory). This evidence concerns the gene CALR and Keratoconjunctivitis sicca.