[19] Wasko et al. demonstrated that agents which inhibit either farnesyl diphosphate synthase (FDPS) or GGPP synthase (GGDPS) induce autophagy in prostate cancer cells in a manner which appeared to be dependent on impairment of geranylgeranylation of GGTase II substrates, Rab GTPases. This evidence concerns the gene FDPS and Familial prostate cancer.