Longer drug treatment increased the soluble forms of MICA and ULBP2, the two molecules reportedly cleaved and released into the extracellular space as negative feedback ligand-mediated NK regulation [14], in culture medium of breast carcinoma cells at 48 and 72 hours after docetaxel treatment compared to untreated cells (Supplementary Figure S1), partly explaining their reduction on the cell membrane. The gene discussed is MICA; the disease is breast carcinoma.