In fact, it was observed that tumor areas in both T/H (Figure 5A) and CRL (Supplemental Figure S5A) were largely devoid of immunostaining for mitochondrial proteins such as β-F1-ATPase, Hsp60 and IF1, suggesting that progression of liver cancer is concurrent with the repression of mitochondrial biogenesis [26]. The gene discussed is ATP5IF1; the disease is liver cancer.