FBN1 and familial mitral valve prolapse: Indeed, the syndromic forms of MVP have been linked to several genes such as FBN1 (Fibrillin-1) in Marfan syndrome [2], TGFBRs (TGFβ receptors) in Loeys-Dietz syndrome [3], COL-1 (Collagen-1) in Ehlers-Danlos syndrome [4], while the FLNA (Filamin A) gene was associated to non-syndromic X-linked myxomatous valvular dystrophy (XMVD) [5,6].