Although FlnA mutations have been associated to important and various congenital developmental diseases, including periventricular heterotopy (PVH) [9], Melnick-Needles syndrome (MNS) [10], and otopalatodigital syndrome (OPD), it is important to note that the patients bearing MVP-associated FlnA mutations only suffer from valvular affections, suggesting similar but specific mechanisms are at work for these MVP-associated FlnA-mutations. Here, FLNA is linked to Osteodysplasty, Melnick-Needles type.