CFTR and colon adenocarcinoma: In Calu-3 cells derived from a pulmonary adenocarcinoma, treatment of cells for more than 24h (corresponding to chronic inflammation conditions) with a pro-inflammatory cytokine (TNFα) activatedCFTR gene expression at the transcriptional level7, whereas the same treatment reduced CFTR expression in a colon adenocarcinoma-derived cell line (T84)6.