TNF and obesity due to melanocortin 4 receptor deficiency: With the hypertrophy of the adipose tissue, occurs an unbalance in the secretion of pro and anti-inflammatory adipokines, including the tumor necrosis factor alpha (TNF-α), the interleukin-6 (IL-6) and adiponectin, establishing a state of chronic inflammation of low intensity, that represents an important role in the development of obesity-related comorbidities.