SLC5A2 and metabolic dysfunction-associated steatohepatitis: In that study, ipragliflozin, a SGLT2 inhibitor, failed to reverse inflammation and raised both the alanine aminotransferase (ALT) and the aspartate aminotransferase (AST) level, despite only a slight reduction in hepatic lipid accumulation, in methionine choline diet (MCD)-induced NASH model rats [5].