In that study, ipragliflozin, a SGLT2 inhibitor, failed to reverse inflammation and raised both the alanine aminotransferase (ALT) and the aspartate aminotransferase (AST) level, despite only a slight reduction in hepatic lipid accumulation, in methionine choline diet (MCD)-induced NASH model rats [5]. The gene discussed is GPT; the disease is metabolic dysfunction-associated steatohepatitis.