Recently, Xia et al. reported that IL-17A plays a crucial role in stimulating the production of MUC5AC and goblet cell hyperplasia through the act1-mediated signaling pathway, and that IL-17A may be a promising therapeutic target for the management of Th17-dominant CRSwNP patients in China [17]. The gene discussed is IL17A; the disease is chronic rhinosinusitis with nasal polyps.