This protocol of transplantation relied on the generation of alloreactive NK cells with a KIR repertoire unable to bind to host MHC class I molecules, and was associated with a 65% probability of disease-free survival, decreased incidence of relapse, and no increased incidence of graft versus host disease (GVHD) in T-cell-depleted transplants (37). Here, KIR3DL1 is linked to graft versus host disease.