We next investigated SC35p dynamics in naïve and effector T cells utilizing an established virus infection model in which naive (CD44loCD62Lhi) OT-I TCR transgenic CD8+ T cells specific for the ovalbumin peptide (OVA257-264) were adoptively transferred into congenic C57BL/6J (B6) hosts followed by intranasal (i.n.)infection with the A/HKx31-OVA virus (40). This evidence concerns the gene CD8A and viral infectious disease.